TNFR1 Signaling Pathway
| PAG Title | TNFR1 Signaling Pathway |
| PAG ID | WIG000449 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | TNFR1 (a.k.a. p55, CD120a) is the receptor for TNF(alpha) and also will bind TNF(beta). Upon binding TNF(alpha) a TNFR1+ cell is triggered to undergo apoptosis. This critical regulatory process is accomplished by activating the proteolytic caspase cascade that results in the degradation of many critical cellular proteins. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,598 |
| Information Content | Rich |
| Other IDs | M3618 |
| Base PAG ID | WIG000449 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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